These clinical research studies are evaluating investigational treatments for ages 18-75 with MASH/NASH, with or without cirrhosis. These studies are investigating whether these treatments can halt or reverse liver damage caused by MASH/NASH.
Participation lasts 5 months to 4+ years and includes study-related care, health assessments, and regular monitoring by a clinical team. Eligible participants may include ages 18-75 diagnosed with MASH/NASH who have at least two of the following metabolic risk factors: obesity, high triglycerides, reduced HDL cholesterol, type 2 diabetes, or high blood pressure.
Metabolic dysfunction-Associated Steatohepatitis (MASH), previously known as Non-Alcoholic Steatohepatitis (NASH), is a progressive liver disease closely linked to obesity, type 2 diabetes, and metabolic syndrome. It is characterized by excess fat buildup in the liver, along with inflammation and cell damage that can lead to scarring (fibrosis) and, over time, cirrhosis.
Until recently, there were no approved medications specifically for MASH, and management focused primarily on lifestyle changes such as weight loss, diet, and exercise. While some pharmacological options have recently emerged, treatment options remain limited — making ongoing clinical research critical to finding effective therapies for the millions of people living with this condition.
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